Kane played through a fever to score the winner in Monday’s 1-0 win at Fulham but the England captain did not train for three days after the victory at Craven Cottage.
He only returned to training on Friday but wants to be involved at Deepdale.
New loan signing Arnaut Danjuma is available and will come straight into the squad.
Kane is level with Jimmy Greaves’ all-time Tottenham goals record and Spurs assistant manager Cristian Stellini said: “He wants to come with us and be available.
“We know very well that Harry wants to play every game, so we are happy that Harry is involved in the game. But the only situation we have to take care is this.”
Danjuma has joined Spurs on a loan from Villarreal until the end of the season.
“The only player we can realise that is not ready like the others is Arnaut because he is a new player,” said Stellini. “We are happy but we need to give him time to understand everything.”
Ryan Sessegnon and Matt Doherty are expected to come in at wing-back, while Pape Matar Sarr is an option in midfield. The 20-year-old has not played since a difficult north London derby.
Richarlison should make his first start since the World Cup.
Lucas Moura remains out for Spurs, though did score for the Under-21s against Arsenal on Friday night as he took the next step in his recovery from a tendon injury. Bryan Gil is a slight doubt.
Predicted Tottenham XI (3-4-3): Forster; Tanganga, Sanchez, Lenglet; Doherty, Sarr, Bentancur, Sessegnon; Kulusevski, Kane, Richarlison
