ottenham captain Hugo Lloris is out for at least five weeks with a knee injury and back-up goalkeeper Fraser Forster will deputise against Leicester as he starts a run in the team.
Spurs will also be without Cristian Romero, who is suspended after his red card against Manchester City last weekend.
Davinson Sanchez is likely to come into the team for Romero.
Yves Bissouma is facing surgery on a fractured ankle and is set for a spell on the sidelines.
After his brilliant display against Manchester City, Emerson Royal will hope to keep his place in the team at right wing-back ahead of new signing Pedro Porro.
In the absence of Lloris, Harry Kane will captain Spurs.
Kane became Tottenham’s all-time leading scorer last weekend and has 18 goals in 15 Premier League games against Leicester, making them the team he has scored the most against in his career.
Tottenham manager Antonio Conte should be back on the touchline after he missed the Manchester City game after having his gallbladder removed.
The Italian returned to Hotspur Way on Thursday and has travelled with the team.
Tottenham predicted XI (3-4-3): Forster; Sanchez, Dier, Davies; Royal, Hojbjerg, Skipp, Perisic; Kulusevski, Kane, Son.
