After knocking out Barcelona earlier in the Europa League, and with Arsenal also out of the competition, United are favourites to go all the way this season and lift their first European trophy since winning this six years ago.
Erik ten Hag’s side have not lost at Old Trafford since September and will be confident of securing a decent advantage to take to Spain for the second leg of this quarter-final, even with the injury concern over Marcus Rashford.
Sevilla sit 13th in La Liga are are on their third manager of the season, with Julen Lopetegui and Jorge Sampaoli sacked earlier in the campaign.
Where to watch Man United vs Sevilla
TV channel: In the UK, the game will be televised live on BT Sport 1 and BT Sport Ultimate, with coverage beginning at 7pm BST.
Live stream: Subscribers can also catch the contest live online via the BT Sport app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.
