The Red Devils are of course the holders of this competition, having won it last season under Erik ten Hag when they beat Manchester City in the final at Wembley.
United continue to struggle under Ruben Amorim, who faces a huge week as he attempts to salvage some silverware from what has been a hugely disappointing campaign.
Amorim’s side face Real Sociedad in the first leg of their Europa League last-16 tie on Thursday and then host Arsenal in the Premier League next Sunday.
Victory would help build some confidence ahead of the Sociedad tie but United face a tough test against a Fulham side who are enjoying a good season under Marco Silva and are nine points above them in the Premier League table.
But, in a wide open FA Cup with Liverpool, Arsenal, Chelsea and Tottenham all out, United will sense an opportunity.
Here’s everything you need to know about where to watch…
How to watch Manchester United vs Fulham
TV channel: The game will be broadcast for free on BBC One. Coverage starts at 4pm GMT ahead of a 4.30pm kick-off time.
Live stream: The BBC iPlayer and BBC Sport website – which are both free with an email subscription – will offer a live stream.
