Portsmouth are just one point clear of the relegation zone in the Championship and the Gunners will be out to avoid another major giant killing.
Non-League Macclesfield stunned Crystal Palace yesterday and Mikel Arteta will be wary about underestimating Pompey in what will be a hostile atmosphere at Fratton Park.
Arteta is expected to ring the changes but Arsenal should still have enough to comfortably seal a spot in the fourth round.
Arsenal are six points clear at the top of the Premier League and this is the first of four away games in four competitions in the space of nine days for the Gunners, who are targeting a record 14th FA Cup trophy this season.
They were knocked out at this stage by Manchester United last season and Arteta will have one eye on the first round of the Carabao Cup semi-final with Chelsea next week.
But Arteta will be demanding a professional performance from whatever side he puts out.
How to watch Portsmouth vs Arsenal
TV channel: In the UK, the game will be televised live on TNT Sports 1, with coverage starting at 1.30pm ahead of a 2pm kick-off.
Live stream: TNT Sports subscribers can also catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, with expert analysis from Matt Verri at Fratton Park.
