Nunes joined on deadline day from Wolves, in a deal worth £53million, while Doku was an unused substitute for the narrow win over Sheffield United last time out.
Kevin De Bruyne and John Stones are still missing for the Premier League champions, Manuel Akanji should be available again after missing the win at Bramall Lane through illness.
Phil Foden started that game on the bench due to an illness of his own, but came on and has now recovered. He is expected to start with one of Bernardo Silva or Jack Grealish making way.
Newly crowned PFA Player of the Year Erling Haaland scored both home and away against Fulham last season and you would not bet against him adding to that tally this weekend.
Predicted Man City XI: Ederson; Walker, Akanji, Dias, Ake; Rodri, Kovacic; Foden, Alvarez, Doku; Haaland
Injured: De Bruyne, Stones
Doubt: Akanji
Time and date: 3pm BST, Saturday, September 2, 2023
Venue: Etihad Stadium