Title favourites, and league leaders, Arsenal head to Liverpool looking to win at Anfield for the first time in 11 years, while City have Erling Haaland fit again as they travel to bottom-of-the-table Southampton.
A win for Arsenal would send out a huge statement as they get another monkey off their back in a season few predicted.
The weekend starts at Old Trafford as Manchester United welcome Everton looking to avoid another slip-up. Top-four rivals Newcastle face a tough task at Brentford, while Tottenham must get back on track at home to Brighton.
There is a huge relegation clash as Leicester host Bournemouth while Nottingham Forest will hope to pick up points at Aston Villa.
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