Between four and six men and at least one woman, who appeared to be protesting about the Ulez expansion, shouted and interrupted the mayor during a ticketed event to promote his book, Breathe.
They were sat in the middle of the 2,600-capacity hall, about 30 yards from the mayor on stage.
The audience tried to drown out the shouts and called for the protesters to leave as they encouraged the mayor to continue reading extracts from his book.
At one stage, one of Mr Khan’s brothers, who was sat with his wife near the protesters, stood up and told them to be quiet. One man approached him, threatening a fight.
LBC presenter James O’Brien, who was questioning the mayor on stage, warned they would be evicted if the protests continued.
When one man shouted that it was “a lie” that schoolgirl Ella Kissi-Debrah’s death had been caused by air pollution, he was removed by the venue’s security staff.
A second man was evicted shortly before 9pm after shouting obscenities at Mr Khan. The rest of the group then left.
Mr Khan, asked about the protests and the level of abuse he has faced as mayor, said more people supported him than objected to his policies. To applause from the audience, he said his attitude was: “Don’t let the bullies win.”
The Royal Festival Hall had been closed in advance of the event for three hours this afternoon to allow a security sweep. There were bag checks on entry but the protesters, some of whom were drinking, were able to sit in the hall.
More follows.