While the Red Devils had looked to be heading towards the semi-finals, their first-leg lead evaporated in unfortunate circumstances a week ago to send the teams to Spain level on aggregate at 2-2.
Erik ten Hag’s United warmed up for the return fixture with a comfortable win at Nottingham Forest but are contending with a major injury crisis.
Sevilla also won on the weekend but are stuck in mid-table in LaLiga, making this clash potentially definitive for their campaign.
The winner of this tie will meet either Juventus or Sporting CP in the final four.
Date, kick-off time and venue
Sevilla vs Manchester United is scheduled for an 8pm BST kick-off on Thursday, April 20, 2023.
The match will take place at the Estadio Ramon Sanchez Pizjuan.
Where to watch Sevilla vs Manchester United
TV channel: In the UK, the game will be televised live on BT Sport 1, with coverage beginning at 7pm BST.
Live stream: Subscribers can also catch the contest live online via the BT Sport app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.
Sevilla vs Manchester United team news
The suspended Gonzalo Montiel is the key absentee for Sevilla, who have a largely fit squad to pick from.
Marcus Rashford and Luke Shaw travelled to Spain in a major boost for United, though Lisandro Martinez and Raphael Varane are injured.
Alejandro Garnacho, Donny van de Beek and Tom Heaton are ruled out.
Sevilla vs Manchester United prediction
The modern removal of the away goals rule really opens up this tie, as previously Sevilla would have felt very confident of avoiding defeat.
United were largely the better team in Manchester and were unlucky not to win the first leg, but may need to take this one all the way to reach the semi-finals.
A 1-1 draw, 3-3 on aggregate. Man United to win on penalties.
Head to head (h2h) history and results
Sevilla wins: 2
Draws: 2
Man United wins: 0
Sevilla vs Manchester United match odds
Sevilla to qualify: 11/8
Draw (90 mins): 5/2
Man United to qualify: 4/7
Odds via Betfair (subject to change).