Pep Guardiola’s side will have had over a week off since their win over Newcastle followed up success in Athens as they lifted the UEFA Super Cup.
City, while not always the strongest starters, look in ominous form and it will be hugely difficult for the Blades.
Though well-organised, they face an almighty task to stay in the Premier League after a difficult summer.
Here’s everything you need to know.
Date, kick-off time and venue
Sheffield United vs Man City is scheduled for a 2pm BST kick-off time on Sunday 27 August, 2023.
Bramall Lane in Sheffield will host.
Where to watch Sheffield United vs Man City
TV channel: The game will be broadcast on Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HDR.
Live stream: Subscribers will be able to watch on a live stream via the Sky Go website or app.
Sheffield United vs Man City team news
Cameron Archer could make his debut for the hosts after a move from Aston Villa but Rhian Brewster is not fit.
Kevin De Bruyne will miss three to four months of action for City after hamstring surgery, while John Stones and Bernardo Silva are doubts.
New signing Jeremy Doku could make his debut, though Guardiola will miss the game after back surgery so assistant manager Juanma Lillo will take charge.
Guardiola will miss the next two games after back surgery
/ Manchester City FC via Getty ImagesSheffield United vs Man City prediction
It would be an almighty shock if City do not win even without Guardiola on the touchline.
Man City to win 3-0.
Head to head (h2h) history and results
Sheffield United wins: 38
Draws: 34
Manchester City win: 54
Sheffield United vs Man City latest odds
Sheffield United wins: 16/1
Draws: 13/2
Manchester City wins: 2/11
Odds via Betfair and subject to change.